Organic anions of human erythrocytes

Active Transport of Organic Anions across the Human Erythrocyte Membrane

Erythrocytes, which constitute more than 40% of the blood volume and about 3% of the body mass, are an important, although frequently neglected, detoxification organ. The main route of xenobiotic metabolism in erythrocytes goes through the glutathione conjugation process, and subsequently comprises removal of the conjugates via the membrane active transport systems. In human erythrocyte membran...

Ultraviolet Photoelectron Spectroscopy of Organic Anions

Entry of organic acid anions into roots.

Entry of formate, acetate, succinate, and salts of several other organic acids into barley roots takes place chiefly as ions from solutions at pH 5 to 7. The results are in accord with entry of the organic acid predominantly at pH 5 as ions through hydrophylic regions of the limiting membranes rather than by distribution of the undissociated acid to lipid-rich regions, as has previously been he...

Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions.

The human multidrug resistance protein MRP1 and its homolog, MRP2, are both suggested as being involved in cancer drug resistance and the transport of organic anions. We expressed MRP1 and MRP2 in Spodoptera frugiperda ovarian cells and compared their ATP-dependent transport properties and vanadate-sensitive ATPase activities in isolated membrane vesicles. Both MRP1 and MRP2 actively transporte...

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells.

Hepatobiliary elimination of many organic anions is initiated by OATP1B1 (OATP2, LST-1, OATP-C), OATP1B3 (OATP8), and OATP2B1 (OATP-B), which are the predominant uptake transporters of human hepatocytes. Thereafter, the unidirectional efflux pump ABCC2 (multidrug resistance protein 2) mediates the transport of organic anions, including glutathione conjugates and glucuronosides, into bile. In th...